Stem cell culture supernatant therapy
What is STEM TAP therapy?
Stem cell culture supernatant is the supernatant of the solution used to culture and grow stem cells. Stem cell culture supernatant does not contain stem cells themselves, but contains more than 2,000 types of physiologically active substances, including nucleic acids, microRNA, peptides, amino acids, coenzymes, and proteins. It is believed that these components act both inside and outside the cells to produce effects similar to those of stem cell therapy, such as tissue repair, inflammation suppression, and cell activation.
What are exosomes?
Exosomes are tiny nano-sized sac-like structures secreted by cells that play an important role in intercellular communication. They contain signaling substances such as nucleic acids (microRNA and messenger RNA) and proteins, and it is believed that these components play an important role in promoting tissue repair, suppressing inflammation, and regulating the immune system by transmitting information to other cells.
Effects of stem cell culture supernatant
Stem cell culture supernatant is believed to have the following effects:
1.Anti-inflammatory effect
It promotes healing in inflamed areas and also reduces pain.
2.Wound healing effect
It repairs damaged cells and promotes faster wound healing.
3. Tissue and nerve repair effect
When tissues such as internal organs, muscles, and peripheral nerves are damaged, it promotes the repair of the affected area. Cell division is activated in the damaged tissue, increasing the tissue's regenerative ability and restoring function.
4.Immunomodulatory effect
It regulates immune function to a normal state to prevent allergies caused by abnormal immune responses.
5. Blood vessel regeneration/angiogenesis effect
When blood flow is interrupted due to arteriosclerosis or other reasons, the resumption of blood flow is promoted by the angiogenesis of collateral circulation.
6. Antioxidant effect
It removes active oxygen generated in the body and prevents cell aging and cancer.
7. Scavenging effect of activated oxygen
It helps to recover from fatigue and prevent lifestyle-related diseases.
8. Rejuvenation and beauty effects
By applying the tissue repair effect, it aims to prevent wrinkles and sagging and improve aging.
Symptoms and problems that can be improved with stem cell culture supernatant therapy
By applying the tissue repair effect, it aims to prevent wrinkles and sagging and improve aging.
Bone, muscle and joint symptoms
Osteoarthritis
Joint pain
Lower back pain (hernia, sudden lower back pain)
Stiffness throughout the body (especially the back)
Stiff shoulders
frozen shoulder
fracture
Muscle strain
gout
Finger joint pain
Bone, muscle and joint symptoms
headache
Headache
Fatigue
Dizziness/lightheadedness
Sleep disorders (insomnia, night sweats, waking up during the night)
chronic pain
Rheumatic diseases
Promoting wound healing
Improvement of postoperative sequelae
reduced immunity
Swelling
hangover
hair
Hair loss
Thinning hair
Hair elasticity
Chewy
Gynecological symptoms
infertility
Menopause
skin symptoms
Rough skin
Vitiligo
Rash
Burn marks
vascular symptoms
arrhythmia
Peripheral circulatory disorders
arteriosclerosis
Myocardial infarction
cerebral infarction
Neurologic symptoms
Neuralgia
Numbness
Dementia
Diabetic neuropathy
motor paralysis
Paresthesia
Ophthalmological symptoms
Eye strain
Presbyopia
floaters
decreased visual acuity
diabetic retinopathy
Urological symptoms
Frequent urination
Urinary incontinence
Erectile Dysfunction (ED)
Symptoms caused by the liver and pancreas
dyslipidemia
hyperglycemia
respiratory symptoms
pneumonia
asthma
Beauty and anti-aging care
Age-related skin aging
Firmness, wrinkles, and age spots
Regulating skin turnover
Difference from stem cell therapy
Stem cell supernatant therapy holds great promise as a new option in regenerative medicine. It is garnering attention as a treatment that can be started easily because it does not require cell collection and can be started on the same day.
On the other hand, if you are looking for a lasting effect or a direct regenerative effect from the cells themselves, stem cell therapy may be more suitable.
At our clinic, we propose the best treatment plan for each patient based on their needs and concerns.
Factors contained in stem cell culture supernatant
EGF (transforming growth factor)
A growth factor produced by various cells such as epithelial cells and endothelial cells, involved in regulating the migration and proliferation of mesenchymal cells, promoting the proliferation and regeneration of damaged tissue.
VEGF (vascular endothelial growth factor)
It is a growth factor that plays an important role in angiogenesis, inducing cell division and differentiation, resulting in the formation of new blood vessels that branch off from existing blood vessels.
TGF-β (transforming growth factor)
Growth factors regulate cell proliferation, growth, differentiation and motility, and also play an important role in the reconstruction of cell tissues, wound healing, inflammation and immunity.
HGF (hepatocyte growth factor)
A growth factor that promotes proliferation of hepatocytes involved in protein synthesis and storage, carbohydrate conversion, cholesterol, detoxification, degeneration, and excretion of xenobiotics.
KGF (keratinocyte growth factor)
A mitogen that promotes angiogenesis and wound healing, and a growth factor that assists in the production of keratin, which is necessary for the formation of hair and skin.
IGF (insulin growth factor)
A growth factor that has a wide range of effects, including promoting cell proliferation and differentiation and protein assimilation, and is produced by growth hormone, which is secreted in large amounts during puberty.
PDGF (Platelet-derived Growth Factor)
A growth factor produced by various cells, including epithelial cells and endothelial cells, that is involved in regulating the migration and proliferation of mesenchymal cells, promoting the proliferation and regeneration of damaged tissue.
FGF (fibroblast growth factor)
It is a type of growth factor involved in angiogenesis and wound healing, and plays an important role in the proliferation and differentiation processes of a wide range of cells and tissues.
IL-7 (Interleukin 7)
It is one of the physiologically active substances that promotes cell proliferation and is an important regulatory factor for survival, proliferation, and maturation.
GM-CSF (granulocyte-monocyte colony-stimulating factor)
A hematopoietic growth factor that promotes cell survival and activation, induces differentiation into pluripotent hematopoietic stem cells, and functions as an immunoregulatory factor.
EPO (erythropoietin)
A growth factor that promotes the production of red blood cells and is produced primarily in the kidneys.
TSG-6 (anti-inflammatory humoral factor)
In addition to suppressing inflammation, this growth factor is attracting attention as a treatment for arteriosclerosis.
TPO (hematopoietic factor)
It is a hematopoietic factor involved in the proliferation and differentiation of platelet precursor cells, and is thought to be an important factor in the production of hematopoietic cells.
TIMP (MMP inhibitor)
It inhibits the breakdown of tissue collagen and elastin by MMP*, preventing fibrosis.
*MMP (matrix metalloproteinase) is a type of enzyme that breaks down proteins between cells, such as collagen, proteoglycan, and elastin. It is said that abnormal expression of MMP is involved in the development of various diseases, including cancer, inflammation, multiple sclerosis, and periodontal disease.
STEM TAP Therapy Process
1. Doctor's examination and counseling
If your suitability for stem cell culture supernatant therapy is confirmed during your consultation and you agree to the treatment, it can be performed on the day of your appointment.
2. Stem cell culture supernatant therapy (administration)
It will be administered in the most appropriate way depending on the treatment.
3. Follow-up
We will conduct examinations 1, 3, 6, and 12 months after administration of stem cell culture supernatant to check whether the treatment is safe and effective. If necessary, we will conduct tests using various testing equipment.
Treatment in a private room
Treatment is carried out in a private room to ensure patient privacy.
Risks and Side Effects
side effects
To date, no serious side effects have been reported.
Possible side effects that have been reported include the following:
Swelling, redness, and pain at the injection site
Temporary fever and fatigue
Allergic reactions
Changes in physical condition such as headache, dizziness, nausea
If you have any concerns or changes in your physical condition, please consult your doctor immediately. Our clinic provides safe and secure regenerative medicine through pre-treatment counseling and follow-up after treatment.
About this treatment
Medicines, etc.: The medicines used in this treatment are not approved drugs under the Pharmaceuticals and Medical Devices Act.
Source: Purchased from DC-BIOTECH Co., Ltd.
Availability of other domestically approved drugs: There are no other domestically approved drugs with the same ingredients or properties.
Information on safety in other countries: There have been no reports of serious safety issues in other countries.
This product is not eligible for relief under the Pharmaceutical Adverse Reaction Relief System or the Biological Product Infection Relief System.
Points to note
If you receive exosome infusion therapy, you will not be able to donate blood as a general rule. This is because exosomes contain human-derived components, and the risk of infection with unknown viruses cannot be completely eliminated. However, you will be able to receive blood transfusions.
Pricing & Plans
This treatment is an elective medical treatment. Since elective medical treatment is not covered by the public insurance system, you will be responsible for all medical expenses.
For patients overseas
If patients residing overseas wish to visit our hospital for medical examination or consultation, in order to ensure smooth and safe medical treatment, as a general rule, they will be asked to complete the procedures through a medical coordination company.
There are separate fees for those coming to Japan from overseas for treatment.
For more information, please contact our International Department.